J Res Clin Med. 2024;12: 7.
doi: 10.34172/jrcm.32220
  Abstract View: 229
  PDF Download: 217

Original Article

Frequency of dry eye syndrome in patients with multiple sclerosis: A cross-sectional case-control study

Rana Sorkhabi 1 ORCID logo, Siamak Khavandi 1* ORCID logo, Hormoz Ayromlou 2, Mohammad Hosein Ahoor 1, Mehdi Mohammadkhani 1, Elsa Tabibzadeh 3

1 Department of Ophthalmology, Tabriz University of Medical Sciences, Tabriz, Iran
2 Department of Neurology, Tabriz University of Medical Sciences, Tabriz, Iran
3 Department of Anesthesiology and Intensive Care, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Email: siamak3ad@gmail.com


Introduction: Demyelination of the nerve fibers of the central nervous system is a main pathology of multiple sclerosis (MS), in which inflammation plays a major role. Studies have shown that inflammation is the leading cause of dry eye disorder. To investigate the association between inflammation and both diseases, we aimed to estimate the prevalence of dry eye syndrome (DES) in MS patients and its correlation with the severity of the disease and disability status.

Methods: We enrolled 100 MS patients randomly and 100 healthy controls. DES was evaluated by Dry Eye questionnaire and Scoring System (DESS), tear break-up time (TBUT), tear meniscus height (TMH), and Schirmer 1 & 2 tests in subjects. Furthermore, the leading disability in MS was assessed by a clinician (neurology professor) using the related questionnaire (Expanded Disability Status Scale).

Results: According to the TBUT, THM, and Schirmer tests, the number of subjects with abnormal results was significantly higher in the MS group than in the control group. The severity of DES measured by the DESS was also higher in the MS group compared to control group. Also, there was a significant relationship between increasing disability and abnormal dry eye tests, especially in MS patients with EDSS scores>4.

Conclusion: The present study highlights the importance of considering dry eye disorder in MS patients as a possible consequence of inflammation. Also, our results suggested a significant relationship between dry eye disorder and the EDSS scores.

First Name
Last Name
Email Address
Security code

Abstract View: 230

Your browser does not support the canvas element.

PDF Download: 217

Your browser does not support the canvas element.

Submitted: 05 Mar 2022
Accepted: 09 Jun 2023
ePublished: 26 Mar 2024
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)