Chryseobacterium indologenes is an uncommon human pathogen that is aerobic, non-fermentative, and oxidase and indole positive. Its clinical relevance has yet to be fully determined. An increase in deadly infectious cases has been recorded in recent years, mostly in patients of older age group and immunocompromised states as a result of C. indologenes infection of medical equipment involving fluids and implanted devices. Because C. indologenes is resistant to the majority of antibiotics, therapy is challenging and this bacterium is thought to be an emerging cause of high mortality in critically ill patients. In our study, we describe a case of C. indologenes producing bacteremia in an elderly female patient with a history of ovarian cancer and hepatitis B infection who had underwent a right hemicolectomy with end ileostomy and a distal mucus fistula and was effectively treated with levofloxacin.