J Res Clin Med. 2024;12: 2.
doi: 10.34172/jrcm.2024.32207
  Abstract View: 302
  PDF Download: 259

Case Report

Donepezil overdose and its atypical clinical presentations: A case report

Mohammad Delirrad 1 ORCID logo, Habib Ahmadi 2, Nader Aghakhani 3* ORCID logo

1 Department of Forensic Medicine, School of Medicine, Food and Beverages Safety Research Center, Taleghani Hospital, Urmia University of Medical Sciences, Urmia, Iran
2 Fellowship in Toxicology, Kermanshah Urmia University of Medical Sciences, Kermanshah, Iran
3 Food and Beverages Safety Research Center, Urmia University of Medical Sciences, Urmia, Iran
*Corresponding Author: Nader Aghakhani, Email: nader1453@umsu.ac.ir


Donepezil [Aricept®] is a centrally acting reversible acetylcholinesterase inhibitor. We are reporting an unusual case of a 49-year-old male patient with a history of gastric bypass surgery who mistakenly ingested 200 mg of donepezil. During the hospital stay, atypical presentations such as tachycardia, disorientation, mydriasis, and ophthalmic myoclonus were diagnosed. He had experienced convulsions several times and developed rhabdomyolysis. The patient gradually improved under supportive management and was discharged from the hospital after seven days. The authors hope that reporting this case will provide both context for clinicians to be aware of its overdose that may be presented by atypical manifestations or side effects, along with the main muscarinic anticholinergic presentations.
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Submitted: 12 Feb 2022
Revision: 21 Feb 2023
Accepted: 23 Feb 2023
ePublished: 09 Jan 2024
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