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J Res Clin Med. 2022;10(1): 3.
doi: 10.34172/jrcm.2022.003
  Abstract View: 145
  PDF Download: 148

Original Article

Conflict effects of autophagy on cellular senescence in advanced ages: A systematic review

Aysa Rezabakhsh 1,2* ORCID logo, Hossein Hosseinifar 3, Nafiseh Vahed 3, Fatemeh Salehnia 4

1 Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Emergency Medicine Research Team, Tabriz University of Medical Sciences, Tabriz, Iran
3 Evidence-Based Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4 Research Development & Coordination Center, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Aysa Rezabakhsh, Email: aysa.rezabakhsh@gmail.com

Abstract

Introduction: Recently, autophagy as a highly conserved catabolic intracellular process is considered a promising therapeutic target, particularly in pathological alternations under aging conditions. This systematic review was designed to qualitatively analyze the interaction between autophagy and aging in various organs of animal models.

Methods: Based on our primary search, 9478 articles were identified, and following the screening, ultimately, 80 full texts were included to proceed with further analysis. Next, using SPSS software, data analysis of autophagy and aging-related markers and autophagy alternation throughout aging, was performed.

Results: Despite debatable results, we established that the most of studies showed that the autophagy process reduced in different aged organs significantly.

Conclusion: The outcomes demonstrated that autophagy induction during aging was inferior to those reports that indicated the therapeutic potential of autophagy. Taken together, it should be considered that autophagy inducers could be counted as anti-aging agents.

Keywords: Aging, Aging-related biomarkers, Autophagy, Autophagic biomarkers, Cellular senescence
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Submitted: 11 Mar 2021
Revision: 22 Mar 2021
Accepted: 22 Mar 2021
ePublished: 09 Feb 2022
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