J Res Clin Med. 2021;9: 26.
doi: 10.34172/jrcm.2021.026
  Abstract View: 1077
  PDF Download: 3201

Case Report

Is there a link between COVID-19 and Creutzfeldt-Jakob Disease? a Case Report

Ehsan Nasiri 1 ORCID logo, Amirreza Naseri 1 ORCID logo, Mohammad Yazdchi 2 ORCID logo, Mahnaz Talebi 2* ORCID logo

1 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
2 Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Email: Talebi511@yahoo.com


Creutzfeldt-Jakob Disease (CJD) is a rare rapidly progressive neurodegenerative disease. The diagnosis of CJD is based on magnetic resonance imaging (MRI) findings, electro-encephalography (EEG), or 14-3-3 protein detection. We report a case of a previously-healthy 72 years old woman, with evidence of coronavirus disease 2019 (COVID-19), who complained of behavioral changes and rapidly progressive dementia. While hospitalization, she didn't have orientation to time and place and repeated an irrelevant sentence in response to questions. Also, anomia and impaired comprehension was observed. Myoclonic jerks, abnormal signal intensity at bilateral parieto-occipital cortices in MRI, periodic sharp wave complexes in EEG, and increased lactate dehydrogenase in cerebrospinal fluid (CSF), highly recommended CJD for her. This is the second case of CJD after COVID-19 during this pandemic, which can be an alarm to clinicians about the silent impact of COVID-19 on the central nervous system.
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Submitted: 13 Feb 2021
Revision: 21 Feb 2021
Accepted: 22 Feb 2021
ePublished: 25 May 2021
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