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J Res Clin Med. 2022;10(1): 5.
doi: 10.34172/jrcm.2022.005
  Abstract View: 97
  PDF Download: 94

Original Article

Congenital diaphragmatic hernia: Prognostic value of hernia sac and size of defect

Davoud Badebarin 1 ORCID logo, Saied Aslanabadi 1 ORCID logo, Masoud Jamshidi 1 ORCID logo, Nazila Hasanzadeh 1 ORCID logo, Mir Kazem Gheibi 2* ORCID logo

1 Pediatric Health Research Center, Tabriz Medical Sciences, Tabriz, Iran
2 General Surgeon, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Mir Kazem Gheibi, Email: Gheibimirkazem@gmail.com

Abstract

Introduction: Congenital diaphragmatic hernia (CDH) is a congenital malformation with challenging management. The aim of this study was to evaluate the effect of the presence of hernia sac and defect size on the prognosis of CDH in Tabriz children’s hospital.

Methods: In this prospective study, all the infants with the diagnosis of CDH that were admitted to the Tabriz children’s hospital since 2016-2019 were enrolled. The presence or absence of a hernia sac was evaluated, and the largest diameter on diaphragmatic defect was measured before the repair. Postoperative outcomes, including instability, duration of mechanical ventilation, mortality rate, or hospital discharge were obtained and analyzed.

Results: Over the study period, 30 patients with CDH met the inclusion criteria, consisting of 15 males and 15 females. Fifteen cases were diagnosed during the first 24 hours of life and 16 cases experienced hypoxia in the first hour after birth. Defect size was significantly smaller in survived patients (P=0.041). Postoperative death occurred in 9 (42.85%) patients without a hernia sac. Results showed that none of the cases with hernia sac expired (P=0.035).

Conclusion: In our study, the presence of the hernia sac was related to a lower postoperative mortality rate. Defect size in survived group was also smaller. It can be suggested that the presence of hernia sac and lower diameter of defect size act as good prognostic factors in the outcome of patients with CDH.

Keywords: Congenital diaphragmatic hernia, Defect size, Hernia sac
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Submitted: 16 Jan 2021
Revision: 22 Apr 2021
Accepted: 09 May 2021
ePublished: 12 Mar 2022
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