J Res Clin Med. 2020;8(1): 35.
doi: 10.34172/jrcm.2020.035
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Original Article

Platelet large cell ratio (P-LCR) in predicting acute coronary syndromes before aspirin use

Erdal Tekin (Emergency Medicine)* ORCID logo, Mustafa Bayraktar ORCID logo, Muhammet Celik, Ibrahim Ozlu


Objective: Platelet Large Cell Ratio (P-LCR) test is one of the test parameters that is routinely calculated in the hemogram test, and expressed as the ratio of platelets with platelet volume. Large platelets are relatively younger and contain more intracellular granules, which means platelets have more thrombogenic potential. In the literature investigating the relationship between acute coronary syndrome and P-LCR levels, the use of aspirin in patients and its effects on hemogram parameters were ignored. In our study, for the first time in the literature, the relationship between P-LCR levels and acute coronary syndromes in patients were investigated by exclusion of the influences of the aspirin in hemogram by means of including the patients who has not been used aspirin yet. Method: Retrospectively, patients aged 18-70, were scanned and whom hemogram tests were performed before aspirin usage were included. A total of 109 patients diagnosed with Unstable Angina (UA), Non-ST Elevation Myocardial Infarction (NSTEMI) and ST-Elevation Myocardial Infarction (STEMI) were included and compared in the study. Results: The mean P-LCR values were 23.61% (95% CI: 21.97-25.25) in UA patients; 28.34% (95% CI: 24.86-31.83) in NSTEMI; and 25.71% (95% CI: 22.07-29.35) in STEMI patients. There was a statistically significance between the P-LCR values of the groups (p=0.022). Conclusion: P-LCR increase was statistically significant in acute coronary syndromes without being influenced by the aspirin usage.
Keywords: Platelet Large Cell Ratio, Aspirin, ST Elevated Myocardial Infarction, Non-ST-Elevation Myocardial Infarction, Unstable Angina
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Submitted: 15 Jun 2020
Revision: 27 Jun 2020
Accepted: 28 Jun 2020
ePublished: 18 Jul 2020
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