Platelet large cell ratio (P-LCR) in predicting acute coronary syndromes before aspirin use

Abstract

Introduction: Platelet large cell ratio (P-LCR) test is one of the test parameters that is routinely calculated in the hemogram test, and expressed as the ratio of platelets with platelet volume greater than 12 fL. Large platelets are relatively younger and contain more intracellular granules, meaning that platelets have more thrombogenic potential. In the literature investigating the relationship between the acute coronary syndrome and P-LCR levels, the use of aspirin in
patients and its effects on platelet parameters were ignored. In our study, for the first time
in the literature, the relationship between P-LCR levels and acute coronary syndromes were investigated by means of including the patients before they took aspirin which ensures that P-LCR test is not affected by aspirin.
Method: Retrospectively, patients aged 18-70 years were screened and those whose hemogram tests were completed before aspirin usage were included. A total of 109 patients diagnosed with unstable angina (UA), non-ST elevation myocardial infarction (NSTEMI) and ST-elevation myocardial infarction (STEMI) were included and compared in the study.
Results: The mean P-LCR values were 23.61% (95% CI: 21.97-25.25) in UA patients, 28.34% (95% CI: 24.86-31.83) in NSTEMI, and 25.71% (95% CI: 22.07-29.35) in STEMI patients. There was a statistically significant difference between the P-LCR values among the groups (p=0.022).
Conclusion: The increase in P-LCR, free of aspirin effects, was found to be statistically significant in acute coronary syndromes.

Keywords: Plateletl arge cell ratio, Aspirin, ST elevated myocardial infarction, Non-ST-elevation myocardial infarction, Unstable angina