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J Res Clin Med. 2020;8: 45.
doi: 10.34172/jrcm.2020.045
  Abstract View: 522
  PDF Download: 396

Original Article

NT-Pro-BNP levels during spontaneous breathing test and its association with successful weaning in patients undergoing mechanical ventilation in the Intensive Care Unit: Original Article

Haleh Mikaeili 1 ORCID logo, Katrin Bioukaghazadeh 2* ORCID logo, Masoud Nazemiyeh 1 ORCID logo, Somaieh Matin 3 ORCID logo

1 Associate Professor of Pulmonary Diseases, Department of Internal Medicine, School of Medicine, Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Department of Internal Medicine (Pulmonary Division), School of Medicine, Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Assistant Professor of Internal Medicine, Department of Internal Medicine, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
*Corresponding Author: Email: Katrinbioukaghazadeh@gmail.com

Abstract

Introduction: Weaning of the patient is one of the important medical challenges. One of the most important causes of failure in weaning is cardiovascular disorders. NT-Pro-BNP is a serum marker for cardiac dysfunction. This study conducted to evaluate the level of NT-Pro-BNP during the spontaneous breathing test (SBT) in patients undergoing mechanical ventilation in ICU and its association with successful weaning. Methods: In this cross-sectional study, we enrolled 42 intubated patients who were admitted to the ICU ward of Imam Reza Hospital and were clinically weaned. After obtaining informed consent, SBT was started for the patient. One and a half hours after SBT onset, a venous blood sample was obtained and the patients were followed for SBT test success and the results were recorded. Patients were extubated in stabilized condition or continued mechanical ventilation if needed. Then Data were analyzed. Results: SBT was successful in 45.2% of patients. 54.8% of patients were male. The most common cause of hospitalization was COPD (35.7%). The mean age of patients with successful SBT was 67.53±6.14 years and in patients with unsuccessful SBT was 68.70±5.44 years. There was a significant difference between NT-Pro-BNP levels half an hour after SBT between two groups of patients with successful (7.15±31.18) and unsuccessful (59.61±196.51) SBT. NT-ProBNP changes before and half an hour after SBT in both groups were statistically significant. Conclusion: NT-Pro-BNP is a predictor criteria of success in weaning in patients and as the level of NT-Pro-BNP increases, the rate of failure in weaning increases.
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Submitted: 15 May 2020
Revision: 25 Aug 2020
Accepted: 25 Aug 2020
ePublished: 06 Dec 2020
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