J Res Clin Med. 2020;8(1): 41.
doi: 10.34172/jrcm.2020.041
  Abstract View: 13
  PDF Download: 23

Original Article

Evaluation of the relation between monocyte count and angiographic thrombosis burden in patients with myocardial infarction with STEMI under PPCI treatment

Ahmad Separham 1 ORCID logo, Mohammad Abbaszadeh 2, Hanieh Sakha 3 ORCID logo, Ali Heidari Sarvestani 4* ORCID logo

1 Associate Professor of Cardiology, Tabriz University Of Medical Science, Tabriz, Iran
2 Fellowship of Interventional Cardiology, Tabriz University of Medical Science, Tabriz, Iran
3 PHD, Islamic Azad University, Tehran North Branch, Tehran, Iran
4 Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


Introduction: Complete thrombotic occlusion of a major epicardial coronary artery is the common pathophysiological mechanism of acute ST-segment elevation myocardial infection (STEMI). Intravascular thrombosis is associated with poor prognosis in patients with STEMI. Methods:In this study, we enrolled 400 patients with STEMI undergoing PPCI . Based on TIMI ratings of the patients and reviewing their angiographic film, they were divided into two groups with high thrombus burden and low thrombus burden. Then, Monocytes were measured in two groups with higher and lower thrombus. Results:A total of 400 patients with STEMI (mean age of 58.71 ± 12.31, 80.5% male) who underwent PPCI enrolled in this study. There were no significant differences between the low thrombus and high thrombus group in In terms of diabetes, high blood pressure, previous history of MI and cardiac troponin levels, However, patients with high thrombus had lower EF .(p value < 0.001). Based on the multivariate analysis result, the amount of circulating monocytes during hospitalization is an independent factor in predicting the rate of thrombosis in angiography. Odds ratio= 3.099 , p value=0.019 .Analysis of the receiver-operating characteristic found an optimal monocyte count cut-off value to be ≤0.60*104 in predicting a high thrombus burden score. Conclusions: The results of the study showed that the number of monocytes is a predicator of high intracoronary thrombus burden in patients with acute STEMI and patients can be treated with antithrombotic treatments.
Keywords: Myocardial Infarction, Monocytes, Percutaneous Coronary Intervention
First Name
Last Name
Email Address
Security code

Abstract View: 13

Your browser does not support the canvas element.

PDF Download: 23

Your browser does not support the canvas element.

Submitted: 13 May 2020
Revision: 09 Jul 2020
Accepted: 10 Jul 2020
ePublished: 07 Oct 2020
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)