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J Res Clin Med. 2020;8(1): 24.
doi: 10.34172/jrcm.2020.024
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Original Article

Role of Vagal Ischemia on Peyer Patches Destiny: First Experimental Study

Sevilay Ozmen * ORCID logo, Onur Ceylan, Mehmet Dumlu Aydin, Erdem Karadeniz, Nazan Aydin, Elif Oral Ahiskalioglu, Tuba Demirci, Ismail Malkoc, Elif Demirci

Abstract

Introduction The vagal network has a major potential role in the immune-life of Peyer’s patches, but there is no satisfying information if vagal ischemia causes Peyer’s patches disruption following subarachnoid hemorrhage. Methods Twenty-two rabbits used as control (GI, n=5), SHAM (GII, n=5), and SAH (GIII, n=12) groups in this experiment. 0.5 cc saline for GII and autologous blood (0.5 cc) injected into cisterna magna for GIII. Four weeks later, they were sacrificed. Their brains, vagal nerves, nodose ganglia, Peyer’s patches, and intestines were examined stereological methods. The Peyer’s patches volumes/intestine volume per cubic millimeter accepted as Peyer’s patches injury score based on a total of 10 points. Results The mean degenerated neuron densities of the nodose ganglia and degenerated axon densities of vagal nerves were 5±2/mm3 and 6±2/mm2 in the GI, 13±4/mm3 and 89±16/mm2 in the GII and 321±83/mm3 and 293±88/mm2 in GIII. The mean Peyer’s patches volumes and Peyer’s patches score were 8±1x106 µm3/mm3 and 0-3 in the GI, 10±3x106 µm3/mm3 and 4-7 in the GII, and 21±5x106 µm3/mm3 and 8-10 in GIII. P<0.0001 in Peyer’s patches volume/Peyer’s patches score/degenerated axon densities of vagal nerves; p<0.0005 in Peyer’s patches volume/Peyer’s patches score/degenerated neuron densities of the nodose ganglia between GI/GIII; P<0.001 in (Peyer’s patches volume/Peyer’s patches score)/degenerated axon densities of vagal nerves; p<0.005 in Peyer’s patches volume/Peyer’s patches score/degenerated neuron densities of the nodose ganglia between GII/GIII; p>0.05 in GI/GII. Conclusion Vagal ischemia/insult may be responsible for Peyer’s patches denervation injury-induced dangerous intestinal immunodeficiency following subarachnoid hemorrhage.
Keywords: intestinal immunodeficiency, peyer patches, subarachnoid hemorrhage, vagal ischemia
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Submitted: 01 May 2020
Revision: 04 Jun 2020
Accepted: 05 Jun 2020
ePublished: 07 Jun 2020
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