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J Res Clin Med. 2020;8(1): 34.
doi: 10.34172/jrcm.2020.034
  Abstract View: 20
  PDF Download: 33

Original Article

Serum level of melatonin in patients with osteoarthritis and its relation with 8-hydroxy-2-deoxyguanosine and vitamin D

Misagh Asanjani Oskoii 1 ORCID logo, Nasrin Khatami 2, Maryam Majidinia 3, Mohammad-Amin Rezazadeh 1, Seyed Mostafa Mir 4, Alireza Sadeghpour 1* ORCID logo, Bahman Yousefi 5,6* ORCID logo

1 Department of Orthopedic Surgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
2 Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, Iran
4 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
5 Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
6 6 Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Alireza Sadeghpour, Email:; Bahman Yousefi, yousefib@tbzmed.ac.ir sadeghpoura@tbzmed.ac.ir

Abstract

Introduction: This study aimed to evaluate the relationship between the serum level of melatonin, 8-hydroxy-2-deoxy guanosine, and vitamin-D in patients with osteoarthritis (OA).

Methods: This study enrolled 47 patients with OA and 40 healthy controls. Serum levels of melatonin and 8-hydroxy-2-deoxy guanosine (8-OH-dG) were assessed. Also, serum levels of bone turnover biomarkers such as calcium, phosphorus, vitamin D, and alkaline phosphatase (ALP) were measured in OA patients and controls.

Results: The serum level of melatonin was significantly lower in OA patients than the controls (6.18±2.25 vs. 11.57±3.87 pg/mL, P<0.05). In contrast, the serum level of 8-OH-dG was significantly increased in OA patients compared to controls (65.21±16.12 vs. 22.51±5.3 ng/dL, P<0.001). There was a negative correlation between serum melatonin and 8-OHdG levels in OA patients (P<0.05). There was a positive correlation between serum melatonin and vitamin D levels in OA patients (P<0.05). We found decreased calcium and vitamin D levels, and increased phosphorus and ALP levels in OA patients compared to controls (P<0.05).

Conclusion: Decreased levels of melatonin and elevated levels of 8-OH-dG might play a role in the pathogenesis of OA. Therefore, melatonin might be involved in decreasing DNA damage and exerting a preventive function in OA.

Keywords: DNA damage, Melatonin, Osteoarthritis, Oxidative stress
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Submitted: 30 Apr 2020
Revision: 06 Jul 2020
Accepted: 06 Jul 2020
ePublished: 22 Aug 2020
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