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J Anal Res Clin Med. 2014;2(1): 17-24.
doi: 10.5681/jarcm.2014.003
  Abstract View: 1091
  PDF Download: 776

Original Research

Role of phosphor and GAS-6 in inflammation in hemodialysis patients in Tabriz, Iran

Jamal Halaj Zadeh 1, Amir Ghorbanihaghjo 2*, Hassan Argani 3, Shahnam Valizadeh 5, Najat Halaj 5, Amirmansour Vatankhah 6, Hakimeh Rezaei Aghdam 7

1 PhD Student, Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Associate Professor, Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Professor, Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Professor, Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
5 MSc Student, Department of Biochemistry, Tabriz University of Medical Sciences, Tabriz, Iran
6 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
7 MSc Student, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Email: ghorbaniamir@hotmail.com

Abstract

Introduction: Inflammation is recognized in up to 50% of chronic kidney disease (CKD) patients, being a common feature of advanced renal disease and crucial mediator of vascularcalcification which may be relevant in CKD. This study was aimed at evaluating the role ofGrowth arrest-specific 6 (Plasma GAS-6) and mineral metabolism abnormalities inhemodialysis (HD) patients. Methods: We enrolled a total of 92 adults including 46 (28 males and 18 females) clinicallystable HD patients and 46 (23 males and 23 females) patients with normal kidney as control group. Plasma GAS-6, Interleukin 6 (IL-6), and high sensitivity C-reactive protein (hsCRP)concentration and biochemical alteration were quantified; as biochemical factors, GAS-6,IL-6, and hsCRP levels were determined by standard methods. Results: Levels of GAS-6 were significantly increased in HD patients compared with normalcontrols (P < 0.001). In HD patients, IL-6, and hsCRP levels were increased compared with controls (P < 0.001). The levels of GAS-6 were directly associated with IL-6 (r = 0.560,P < 0.001) in HD patients. No significant correlation was found between hsCRP and GAS-6levels in HD patients (r = 0.05, P = 0.742). Multiple regression analysis demonstrated thatserum P was independently associated with hsCRP and GAS-6 independently associated with IL-6. Conclusion: Elevated serum P and GAS-6 might play a role in the development ofinflammation in CKD patients. Although our study shows that GAS-6 is directly associated with IL-6 and phosphor with hsCRP, their direct role in vascular calcification and type of theirrelationships need further studies in the future.
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Submitted: 08 Dec 2013
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