Role of phosphor and GAS-6 in inflammation in hemodialysis patients in Tabriz, Iran

Abstract

Introduction: Inflammation is recognized in up to 50% of chronic kidney disease (CKD) patients, being a common feature of advanced renal disease and crucial mediator of vascularcalcification which may be relevant in CKD. This study was aimed at evaluating the role ofGrowth arrest-specific 6 (Plasma GAS-6) and mineral metabolism abnormalities inhemodialysis (HD) patients. Methods: We enrolled a total of 92 adults including 46 (28 males and 18 females) clinicallystable HD patients and 46 (23 males and 23 females) patients with normal kidney as control group. Plasma GAS-6, Interleukin 6 (IL-6), and high sensitivity C-reactive protein (hsCRP)concentration and biochemical alteration were quantified; as biochemical factors, GAS-6,IL-6, and hsCRP levels were determined by standard methods. Results: Levels of GAS-6 were significantly increased in HD patients compared with normalcontrols (P < 0.001). In HD patients, IL-6, and hsCRP levels were increased compared with controls (P < 0.001). The levels of GAS-6 were directly associated with IL-6 (r = 0.560,P < 0.001) in HD patients. No significant correlation was found between hsCRP and GAS-6levels in HD patients (r = 0.05, P = 0.742). Multiple regression analysis demonstrated thatserum P was independently associated with hsCRP and GAS-6 independently associated with IL-6. Conclusion: Elevated serum P and GAS-6 might play a role in the development ofinflammation in CKD patients. Although our study shows that GAS-6 is directly associated with IL-6 and phosphor with hsCRP, their direct role in vascular calcification and type of theirrelationships need further studies in the future.

Keywords: Hemodialysis, Growth Arrest-Specific 6 (GAS-6), Interleukin 6 (IL-6), High Sensitivity C-Reactive Protein