Mehdi Farhoudi
1, Saeed Sadigh-Eteghad
2, Sasan Andalib
2, Manouchehr S Vafaee
3, Mojtaba Ziaee
2, Javad Mahmoudi
2*1 Professor, Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran
2 Instructor, Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran
3 Associate Professor, Department of Neuroscience and Pharmacology, School of Health Sciences, University of Copenhagen,Copenhagen, Denmark
Abstract
Restoring dopamine levels in Parkinson's disese (PD) has been considered as the main symptomatic therapy. In this strategy, long-term administration of L-DOPA results in motor impairments. This necessitates novel approaches in that PD is tackled with lower deleterious side effects. . Modafinil is a wake promoting agent clinically used for treatment of excessive day time sleeping. This medication increases dopamine levels and decreases oxidative stress and can thus exert anti-parkinsonian effect. Therefore, this review will give an account of the probable anti-parkinsonian mechanisms of modafinil.