Association between inflammatory factor, lipid peroxidation and total-antioxidant in non-diabetic patients of coronary artery disease

Abstract

Introduction: The oxidative stress and inflammation are cooperative events involved in atherosclerosis development. In the present study, we assessed the association ofmalondialdehyde (MDA), antioxidant markers, high sensitive C-reactive protein (HS-CRP)and lipid status parameters in non-diabetic patients with coronary artery disease (CAD) orvessel heart disease (VHD). Significant risk factors such as diabetes were excluded from thestudy. Methods: Oxidative stress parameters for example MDA, antioxidant markers including:erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GPX), total antioxidant capacity (TAC), inflammation marker and serum lipid status parameters were measured in 120 subjects including 60 CAD patients (non-diabetic) with angiographically diagnosed CADand 60 CAD-free subjects as a control group, also diabetic patients with malignancy, renal andliver disease, and other disease were excluded from the study. Results: The serum MDA and HS-CRP levels were increased significantly as compared to thecontrols. However, erythrocyte SOD, GPX activities and TAC level were reduced significantly in patients (non-diabetic) (P < 0.05 in all cases). The levels of total cholesterol,triglyceride, and low-density lipoprotein cholesterol (LDL-c) were significantly higher andthat of high-density lipoprotein cholesterol (HDL-c) was significantly lower than those ofcontrols (P < 0.05 in all cases). Conclusion: The association between oxidative stress parameters, antioxidant markers, theinflammation index and lipid status parameters suggest their involvement in atherosclerosis development that may lead to CAD progression. 

Keywords: Total antioxidant, Oxidative stress, Inflammation, Non-diabetic, Coronary Artery Disease