Shahin Abdollahi-Fakhim
1, Saman Rezaeian
2, Hojjat Hosseinpour-Feizi
3, Mohammad Naghavi-Behzad
4, Reza Piri
5*1 Associate Professor, Department of Ear, Nose and Throat (ENT), School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
2 Resident, Department of Ear, Nose and Throat (ENT), School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3 Associate Professor, Department of Orthopedics Surgery, Shohada Educational Medical Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
4 Student of Medicine, Students’ Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
5 Student of Medicine, Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract
Solitary neurofibroma is a benign tumor originating from Schwann
cells in peripheral nerves. In an investigation of 430000 pathologic samples, only
6 cases of neurofibroma had been reported in nose and paranasal sinuses. Present
patient was a 15-year-old girl with left-sided nasal and malar mass, whose CT
scan and MRI showed a non-circumscribed solid mass with total thickness affecting
outer part of nose in left side as well as surface and deep soft tissue. The
mentioned mass underwent excision by sub-labial incision and open rhinoplasty
keeping infra-orbit nerve intact. Pathologic investigation of samples showed
adipose fibroblast and skeletal muscle fibers with proliferation of
spindle-shaped cells and staining was negative for GFAP and positive for S-100
which represents diagnosis of neurofibroma. Main differential diagnoses of
benign tumors of paranasal sinuses and nasal cavity include neurofibroma, fibroma,
leiomyomas, papilloma, and schwannoma. After resection tumor should be
precisely monitored, since there is malignant transformation possibility in
solitary neurofibromas.