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J Anal Res Clin Med. 2014;2(2): 53-56.
doi: 10.5681/jarcm.2014.009
  Abstract View: 859
  PDF Download: 891

Original Research

Apnea testing, a simple prognostic test for diagnosis of brain death

Nemat Bilan 1*, Afshin Ghalehgolab-Behbahan 2, Shadi Shiva 3

1 Professor, Department of Pediatrics, Pediatric Health Research Center, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
2 Associate Professor, Department of Pediatrics, Pediatric Health Research Center, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3 Assistant Professor, Department of Pediatrics, Pediatric Health Research Center, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Email: Bilan@tbzmed.ac.ir

Abstract

Introduction: Brain-death is the end stage of most illnesses that cause brain injury and decrease oxygenation and circulation of brain tissues. Early determination of brain-death isessential to the prevention of expensive modeling in the pediatric intensive care unit (PICU)and reserving facilities for patients with good prognosis. Apnea test is one of the importantbrain-death determining methods in clinical evaluation that can be performed easier and fasterthan other methods. Methods: In a cross-sectional study, 75 patients with brain-death criteria were evaluated from2003-2011. Apnea testing was fulfilled through standard methods. Patients who did not develop spontaneous respiration at PaCo level of 60 mmHg or more were confirmed as brain-dead.

Results: Mean age of patients was 40 months. All patients were comatose, without brainstemreflexes. Cause of coma was status epilepticus in most patients. All patients that had a positive apnea test died after a mean duration of 8 days.Conclusion: All other confirmative methods, irrespective of their accuracy, need complexinstruments and experienced manpower, and are expensive which makes their preparation impossible in most ICU centers. However, apnea test is a simple prognostic method in braindeathconfirmationwith100%accuracy.​

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Submitted: 24 Jan 2014
Accepted: 20 Mar 2014
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