Tabriz University of Medical Sciences Journal of Research in Clinical Medicine 2717-0616 14 1 2026 01 01 Propofol and magnesium sulfate for migraine management in emergency department: A systematic review 35274 35274 10.34172/jrcm.026.35274 EN Seyed Pouya Paknezhad https://orcid.org/0000-0002-0486-5525 Zahra Vand Rajabpour https://orcid.org/0000-0002-2025-0301 Atefeh Javadikia https://orcid.org/0009-0008-2796-1844 Hassan Soleimanpour https://orcid.org/0000-0002-1311-4096 Journal Article 10.34172/jrcm.026.35274 2024 02 24 2025 09 03 Introduction: Migraine is a prevalent condition that can affect 18% of the population. Propofol and magnesium sulfate can exert a therapeutic potential in pain management in patients with acute migraine attacks. Methods: A semi-systematic review to investigate the efficacy of these two drugs was conducted. For the search strategy, PubMed, Embase, Google Scholar, and Cochrane Library were systematically searched. Finally, all randomized clinical trials were included. Results: Eight studies met the criteria for inclusion in our review. Four investigated propofol, and four examined magnesium sulfate. No study compared these two drugs with each other. Conclusion: Propofol demonstrated promising efficacy for pain control. Findings regarding magnesium sulfate were inconsistent. Overall, both agents appeared safe for administration in this patient population.