Tabriz University of Medical Sciences Journal of Research in Clinical Medicine 2717-0616 14 1 2026 01 01 Radiosynovectomy with 188Re-Colloid in Behcet’s Patient with Drug-Resistant Arthritis: A Rare Case Report 35182 35182 10.34172/jrcm.35182 EN Esmaeil Gharepapagh https://orcid.org/0000-0002-3864-6304 Alireza Khabbazi https://orcid.org/0000-0002-9482-6967 Alireza Motamedi https://orcid.org/0000-0001-5658-6635 Sahar Rezaei https://orcid.org/0000-0002-2746-6594 Journal Article 10.34172/jrcm.35182 2024 12 11 2025 05 12 Behçet’s disease is a rare vasculitis that can cause arthritis refractory to standard treatments. This case report describes the use of radiosynovectomy with 188Re-colloid in a patient with drug-resistant Behçet’s arthritis. A 33-year-old man with Behçet’s disease and knee arthritis refractory to conventional therapies underwent radiosynovectomy with 188Re-colloid. The patient experienced symptom relief for 4–8 weeks; however, the symptoms subsequently recurred, leading to surgical synovectomy, which produced unsatisfactory outcomes. This case highlights the complexity of treating arthritis in Behçet’s disease, especially when conventional treatments fail. Although radiosynovectomy with 188Re-colloid may benefit selected patients, this case suggests that it may not be universally effective and highlights the need for further clinical studies to define the full potential of this therapy. In conclusion, this case emphasizes the importance of differential diagnosis in distinguishing the various forms of arthritis associated with Behçet’s disease, since accurate differentiation is essential for avoiding misdiagnosis and ensuring appropriate treatment.