Tabriz University of Medical Sciences Journal of Research in Clinical Medicine 2717-0616 12 1 2024 01 01 The protective effects of Helicobacter pylori: A comprehensive review 17 17 10.34172/jrcm.34509 EN Ali Sadighi https://orcid.org/0000-0003-1066-5965 Zahra Aghamohammadpour Fatemah Sadeghpour Heravi Mohammad Hossein Somi Kourosh Masnadi Shirazi Nezhad Samaneh Hosseini Katayoun Bahman Soufiani Hamed Ebrahimzadeh Leylabadlo https://orcid.org/0000-0002-3790-9176 Journal Article 10.34172/jrcm.34509 2023 07 03 2023 10 15 Previous reports have estimated that approximately half of the world’s population is infected with Helicobacter pylori, the most prevalent infectious agent responsible for gastrointestinal illnesses. Due to the life-threatening effects of H. pylori infections, numerous studies have focused on developing medical therapies for H. pylori infections, while the commensal relationship and positive impacts of this bacterium on overall human health have been largely overlooked. The inhibitory efficacy of H. pylori on the progression of several chronic inflammatory disorders and gastrointestinal diseases has recently raised concerns about whether this bacterium should be eradicated in affected individuals or maintained in an appropriate balance depending on the patient’s condition. This review investigates the beneficial effects of H. pylori in preventing various diseases and discusses the potential association of conditions such as inflammatory disorders with the absence of H. pylori.