Tabriz University of Medical Sciences Journal of Research in Clinical Medicine 2717-0616 12 1 2024 01 01 Prevention and treatment approaches of post-dural puncture headache in obstetric patients: A comprehensive review 25 25 10.34172/jrcm.33444 EN Afshin Iranpour https://orcid.org/0000-0002-0013-3992 Ramakrishna Boddapati Sina Naghilou Amr Aly Abelazem Aly Ata Mahmoodpoor https://orcid.org/0000-0002-4361-6230 Journal Article 10.34172/jrcm.33444 2023 04 30 2024 01 28 Neuraxial anesthesia and analgesia are administered to many patients. The incidence of dural puncture is about 1%, with a higher occurrence in laboring women. Post dural puncture headache (PDPH) develops in 60%-80% of patients after unintentional dural puncture (UDP) which is usually positional and sometimes is accompanied by neck stiffness, photophobia, nausea, or hearing symptoms. It can also drive-up healthcare costs by increasing the length of hospital stay for chronic headache and back pain. PDPH has the potential to cause significant morbidity in the obstetric patients which prolongs the hospital stay. Epidural blood patch (EBP) is considered the gold standard for the management of PDPH. Proper scheduling of analgesics and supporting the patient psychologically as she cares for her newborn is needed. If the intensity of headache is severe, additional agents may be considered. In this review, the different methods and therapeutic approaches for prevention and treatment of PDPH are comprehensively discussed.