Tabriz University of Medical Sciences Journal of Research in Clinical Medicine 2717-0616 10 1 2022 01 01 Seronegative spondyloarthropathy (reactive arthritis) fourteen days following E. coli UTI: Case report 28 28 10.34172/jrcm.2022.028 EN Inderbir Padda https://orcid.org/0000-0001-9626-8965 Rajat Bhatt Glady Mathew https://orcid.org/0000-0001-7626-1512 Gurnaaz Malhi Manpreet Hans Journal Article 10.34172/jrcm.2022.028 2021 08 03 2021 12 09 Reactive arthritis (ReA) is a post-infectious autoimmune condition classified as a seronegative spondyloarthritis (SpA). The current case report presents a 30-year-old female returned for follow-up visits after an acute onset of back pain that progressed to joint swelling and tenderness in both knees, and excruciating pain in her heels and the bottom of her feet four weeks ago. Two weeks prior to the onset of symptoms, the patient was treated for a urinary tract infection (UTI). Due to the symptoms and the inability to ambulate caused by feet pain, the patient was required to admit to a hospital for further evaluation. This case report depicts a unique presentation of ReA following UTI, and the discussion section aiding healthcare professionals in the diagnosis and management of ReA and patient education on ReA and disease course.