Tabriz University of Medical Sciences Journal of Research in Clinical Medicine 2717-0616 10 1 2022 01 01 Conflict effects of autophagy on cellular senescence in advanced ages: A systematic review 3 3 10.34172/jrcm.2022.003 EN Aysa Rezabakhsh https://orcid.org/0000-0003-3942-7848 Hossein Hosseinifar Nafiseh Vahed Fatemeh Salehnia Journal Article 10.34172/jrcm.2022.003 2021 03 11 2021 03 22 Introduction: Recently, autophagy as a highly conserved catabolic intracellular process is considered a promising therapeutic target, particularly in pathological alternations under aging conditions. This systematic review was designed to qualitatively analyze the interaction between autophagy and aging in various organs of animal models. Methods: Based on our primary search, 9478 articles were identified, and following the screening, ultimately, 80 full texts were included to proceed with further analysis. Next, using SPSS software, data analysis of autophagy and aging-related markers and autophagy alternation throughout aging, was performed. Results: Despite debatable results, we established that the most of studies showed that the autophagy process reduced in different aged organs significantly. Conclusion: The outcomes demonstrated that autophagy induction during aging was inferior to those reports that indicated the therapeutic potential of autophagy. Taken together, it should be considered that autophagy inducers could be counted as anti-aging agents.