Tabriz University of Medical Sciences Journal of Research in Clinical Medicine 2717-0616 9 1 2021 01 01 Major bleeding after pronation in severe COVID-19 patient 4 4 10.34172/jrcm.2021.004 EN Rosanna Carmela De Rosa https://orcid.org/0000-0001-8684-0008 Michele Gallifuoco Antonio Romanelli https://orcid.org/0000-0002-6895-6485 Antonio Corcione Journal Article 10.34172/jrcm.2021.004 2020 11 17 2020 12 24 Contrarily to SARS and MERS, the evidence suggests that thromboembolic events are common in patients with COVID-19 pneumonia. The clinical course of severe COVID-19 patients can be complicated with coagulopathy, causing fatal thromboembolic events and requiring adequate treatment with anticoagulant therapy. However, the clinicians should be alerted about the increase of bleeding related to aggressive anticoagulation protocols, especially in critically ill patients who undergo traumatic maneuvers. Here, we reported the case of a 55-year-old woman with symptomatic COVID-19 pneumonia, admitted to the ICU and treated with anticoagulant therapy complicated by major bleeding, probably related to prone position for ARDS treatment.