Tabriz University of Medical Sciences Journal of Research in Clinical Medicine 2717-0616 10 1 2022 01 01 Posterior reversible encephalopathic syndrome in systemic lupus erythematous: A case report 31 31 10.34172/jrcm.2022.031 EN Samaneh Hosseini https://orcid.org/0000-0002-5701-6666 Journal Article 10.34172/jrcm.2022.031 2020 11 12 2021 02 22 Posterior reversible encephalopathy syndrome (PRES) implies to a reversible subcortical vasogenic brain edema, which leads to some acute neurological symptoms. PRES occurs usually in the setting of renal failure, blood pressure fluctuations, cytotoxic drugs, autoimmune disorders, and pre-eclampsia or eclampsia.This is a 40 year old female patient with history of systemic lupus erythematous (SLE) from twenty years ago, admitted to our neurology ward due to severe and refractory headache with multiple convulsive events.Brain MRI showed vasogenic brain edema in occipito-parieto-frontal lobes white matter compatible with PRES. Treatment is omitting of the etiology, but in these patients, discontinuation of immunosuppressive drugs is not possible and probably intravenous methylprednisolone pulse is a good treatment option especially in patient without response to aggressive control of blood pressure.