Tabriz University of Medical Sciences Journal of Research in Clinical Medicine 2717-0616 8 1 2020 02 15 Leptomeningeal metastasis as a presenting manifestation of adenocarcinoma of the lung: a case report 31 31 10.34172/jrcm.2020.031 EN Mazyar Hashemilar https://orcid.org/0000-0002-9522-6963 Behrooz Shokouhi https://orcid.org/0000-0001-9397-0484 Abolhassan Shakeri Bavil https://orcid.org/0000-0001-9397-0484 Elyar Sadeghi-Hokmabadi https://orcid.org/0000-0002-5481-6027 Nasrin Forghani Journal Article 10.34172/jrcm.2020.031 2020 06 03 2020 06 30 Leptomeningeal metastasis (LM) also known as meningeal carcinomatosis is a rare but grave complication seen in the terminal stage of a known primary cancer. We report an uncommon case of LM in a 62-year-old male patient, presenting with neurologic signs and symptoms of increased intracranial pressure at least two months before any evidence of involvement of the primary focus in lung. The prognosis of the disease was poor due to the involvement of central nervous system and bones. It is important to have a high index of suspicion and to consider systemic diseases in differential diagnosis of the syndrome of intracranial hypertension.