Tabriz University of Medical Sciences Journal of Research in Clinical Medicine 2717-0616 1 2 2013 12 30 An analytical review on probable anti-parkinsonian effect of modafinil 58 62 10.5681/jarcm.2013.008 EN Mehdi Farhoudi Saeed Sadigh-Eteghad Sasan Andalib Manouchehr S Vafaee Mojtaba Ziaee Javad Mahmoudi Journal Article 10.5681/jarcm.2013.008 2013 08 02 2013 10 05 Restoring dopamine levels in Parkinson's disese (PD) has been considered as the main symptomatic therapy. In this strategy, long-term administration of L-DOPA results in motor impairments. This necessitates novel approaches in that PD is tackled with lower deleterious side effects. . Modafinil is a wake promoting agent clinically used for treatment of excessive day time sleeping. This medication increases dopamine levels and decreases oxidative stress and can thus exert anti-parkinsonian effect. Therefore, this review will give an account of the probable anti-parkinsonian mechanisms of modafinil.