Tabriz University of Medical Sciences Journal of Research in Clinical Medicine 2717-0616 4 3 2016 08 10 Granulomatous hepatitis triggered by liver Fasciola infestation: A case report 175 180 10.15171/jarcm.2016.029 EN Ali Ghavidel Journal Article 10.15171/jarcm.2016.029 2016 07 03 2016 07 26 Introduction: Liver Fasciola hepatica (FH) infestation is a zoonotic disorder caused by a kind of leaf-like worm. Case Report: In this article the reported patient is a woman who is 54 years old. She had been suffering from stomachaches after every meal from two years ago. Computed tomography (CT), ultrasonography (US) and magnetic resonance retrograde cholangiography (MRCP), proved that right lobe ducts are dilated although there was not any filling defects in the common bile duct (CBD). These findings were most similar with the manifestations of localized segmental cholangiocellular carcinoma (CCC) or granulomatous hepatitis but at the work up, F. hepatica infection was confirmed. The mentioned disease was diagnosed by means of imaging modalities, laboratory analysis including serology and stool examination and was cured by triclabendazole. Conclusion: Humans are infected by consuming undercooked vegetables, with the adult worms inhabiting and laying metacercariae in the biliary system. These organisms induce a chronic inflammatory state in the proximal biliary tree, presumably leading to malignant transformation of the lining epithelium.